Selected Publications

Key: * Indicates corresponding authors.

Statistical Methods in Multi-Omics Integration

  1. Zhang W*, Huang H, Wang L, Lehmann BD, Chen XS* (2025) An Integrative Multi-Omics Random Forest Framework for Robust Biomarker Discovery. Preprint (code)

Epigenetic Biomarkers in ADRD

  1. Zhang W, Young JI, Gomez L, Schmidt MA, Lukacsovich D, Kunkle B, Chen XS, Martin ER, Wang L* (2024) Blood DNA methylation signature for incident dementia: evidence from longitudinal cohorts. Alzheimer’s & Dementia, In press (code)

  2. Zhang W, Lukacsovich D, Young JI, Gomez L, Schmidt MA, Martin ER, Kunkle BW, Chen X, O’Shea DM*, Galvin JE*, & Wang L* (2024). DNA Methylation Signature of a Lifestyle-based Resilience Index for Cognitive Health. Alzheimer’s Research & Therapy, In review (code)

  3. Zhang W, Young JI, Gomez L, Schmidt MA, Lukacsovich D, Varma A, Chen XS, Kunkle B, Martin ER, Wang L* (2024) Critical evaluation of the reliability of DNA methylation probes on the Illumina MethylationEPIC v1.0 BeadChip microarrays. Epigenetics 19(1). https://doi.org/10.1080/15592294.2024.2333660 (code)

  4. Zhang W, Young JI, Gomez L, Schmidt MA, Lukacsovich D, Varma A, Chen XS, Martin ER, Wang L* (2023) Distinct CSF biomarker-associated DNA methylation in Alzheimer’s disease and cognitively normal subjects. Alzheimer’s Research & Therapy 15: 78. https://alzres.biomedcentral.com/articles/10.1186/s13195-023-01216-7 (code)

  5. Silva TC, Zhang W, Young JI, Gomez L, Schmidt MA, Varma A, Chen XS, Martin ER, Wang L* (2022) Distinct sex-specific DNA methylation differences in Alzheimer’s disease. Alzheimer’s Research & Therapy 14: 133. https://doi.org/10.1186/s13195-022-01070-z (code)

Cancer Biomarkers & Therapy Response

  1. Zhang W, Wu C, Huang H, Bleu P, Zambare W, Alvarez J, Wang L, Paty, PB, Romesser PB, Smith JJ*, Chen XS* (2025) Enhancing chemotherapy response prediction via matched colorectal tumor-organoid gene expression analysis and network-Based biomarker selection. Translational Oncology, 52, 102238. ISSN: 1936-5233. https://doi.org/10.1016/j.tranon.2024.102238 (code)

  2. Zhang W, Li E, Wang L, Lehmann BD*, Chen XS* (2023) Transcriptome meta-analysis of triple-negative breast cancer response to neoadjuvant chemotherapy. Cancers 2023; 15(8):2194. https://doi.org/10.3390/cancers15082194 (code)